Dyslexia Research Today is a free monthly online journal that collates and summarizes the latest research about Dyslexia, including details on learning, reading, education, teaching, treatment. | ||||||||
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Interrelationship and familiality of dyslexia related quantitative measures.Schulte-Körne G, Ziegler A, Deimel W, Schumacher J, Plume E, Bachmann C, Kleensang A, Propping P, Nöthen MM, Warnke A, Remschmidt H, König IR Department of Child and Adolescent Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany. schulte1@med.uni-marburg.de Dyslexia is a complex gene-environment disorder with poorly understood etiology that affects about 5% of school-age children. Dyslexia occurs in all languages and is associated with a high level of social and psychological morbidity for the individual and their family; approximately 40-50% have persistent disability into adulthood. The core symptoms are word reading and spelling deficits, but several other cognitive components influence the core phenotype. A broad spectrum of dyslexia related phenotypes, including phonological decoding, phoneme awareness, orthographic processing, short-term memory, rapid naming and basic mathematical abilities, were investigated in large sample of 287 German dyslexia families. We explored the interrelationship between the component phenotypes using correlation and principal component analyses (PCA). In addition, we estimated familiality for phenotypes as well as for the factors suggested by PCA. The correlation between the component phenotypes varied between -0.1 and 0.7. The PCA resulted in three factors: a general dyslexia factor, a speed of processing factor and a mathematical abilities factor. The familiality estimates of single components and factors ranged between 0.25 and 0.63. Instead of analyzing single dyslexia-related components, multivariate analyses including factor analytic approaches may help in the identification of susceptibility genes. Published 21 February 2007 in Ann Hum Genet, 71: 160-75.
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